This is a problem that many people are concerned about. Bladder tumors are the most common malignant tumors in the urinary system, causing great pain to patients. If not treated in time, it will endanger the lives of patients. So, what exactly causes bladder tumors? The following are detailed answers from these experts.
What are the causes of bladder tumors:
1. Long-term exposure to aromatic substances, such as dyes and leather , Rubber, painters, etc., may have a high incidence of bladder tumors.
2. Smoking is also a reason for increasing the incidence of bladder tumors. Recent studies have shown that the metabolism of tryptophan, a carcinogen in the urine of smokers, increased by 50%. When smoking ceases, tryptophan levels return to normal.
3. Abnormal metabolism of tryptophan in the body, abnormal metabolism of tryptophan can produce some metabolites, such as 3-hydroxy-2-aminoacetophenone, 3- Hydroxy-o-aminobenzoic acid can directly affect the synthesis of cellular RNA and DNA. These metabolites are excreted into the bladder through the action of the liver, and after the action of β-glucuronidase, they have carcinogenic effects.
4. Long-term local irritation of the bladder mucosa and chronic local irritation of the bladder wall, such as chronic infection, long-term irritation of bladder stones and urinary tract obstruction, may be induced Factors of cancer. Glandular cystitis and mucosal leukoplakia are considered precancerous lesions, which can induce canceration.
5. Drugs, such as taking phenacetin in large amounts, have been proven to cause bladder cancer.
6. Parasitic disease, if it occurs in the bladder, can also induce bladder cancer.